Validating our results, the VEGF, TLR2 and SOCS3 genes were also differentially expressed in the kidneys from NZB/W-F1 mice 9 months old vs 6 months old as well as the kidneys from patients with LN.36 In agreement with Arazi et al,42 genes such as the ITGAM and FCGR2B were also differentially expressed in the ‘kidney-specific gene signature’. The gene discussed is SOCS3; the disease is lobular neoplasia.