Further supporting the role of the MEK/ERK pathway in high-risk/refractory NB, elegant studies in zebrafish models of NB have demonstrated that the expression of GAB2 or src homology region 2 domain phosphatase (SHP2) (positive regulators of the RAS-MAPK pathway) (Zhang et al., 2017) or loss of the RAS-GAP NF1 (He et al., 2016) potentiate MYCN-amplification-driven NB tumorigenesis. Here, PTPN11 is linked to neuroblastoma.