TP53 and B-cell chronic lymphocytic leukemia: Studies have indicated that ddPCR can be used for the detection and quantitation of HBV cccDNA in the liver of individuals with occult HBV infection (27), for the detection of TP53 deletions and point mutations in chronic lymphocytic leukemia (28), and as a more accurate tool for SARS-CoV-2 detection in low viral load specimens (29).