In the field of the tumor, the TGF-β signal contributes to tumor progression, and in fibrotic diseases, TGF-β promotes the occurrence and development of pulmonary fibrosis.[7–9] In recent years, experiments have shown that TGF-β also affects scleral remodeling and the formation of high myopia.[10,11] The subtypes of TGF-β that can act on the sclera are mainly divided into 1, 2, and 3. The gene discussed is TGFB1; the disease is neoplasm.