This indicated that these genes are linked to some important biological functions.[4] Large population studies have shown that CD3EAP rs735482 polymorphism has a potential impact on the risk of lung cancer and Italics represent significant association with susceptibility of lung cancer.[5,6] CD3EAP rs735482 on Chr19q13.3 were strongly associated with lung cancer risk both in Asian Chinese and in Caucasian Danes.[7]. This evidence concerns the gene POLR1G and lung cancer.