A comprehensive study of the CXC family of chemokines in HNC will help to uncover the molecular mechanisms involved in the development of HNC could unveil novel prognostic and therapeutic targets for the intractable disease.[5] CXCL8 is a chemokine as modulate tumor proliferation, invasion and migration in an autocrine or paracrine manner. This evidence concerns the gene CXCL8 and neoplasm.