CXCR1 and cancer: Studies have suggested that CXCL8 and its cognate receptors, CXCR1 and CXCR2, mediated the initiation and development of various cancers.[6] Relevant studies have shown that the paracrine axis of CXCL9/10/11, CXCR3 regulated immune cell migration, differentiation and activation, leading to tumor inhibition, while the autocrine axis was involved in tumor growth and metastasis.[7] The expression of chemokine CXCL8/9/10/11/13 in a variety of cancers can be better understood from the Previous study, and even promote the growth and development of tumors.