ACKR3 and cancer: These molecules play an important role in the growth, differentiation and activation of many types of cells.[12,16] Chemokines are synthesized mostly by leukocytes and act through their cognate G-protein coupled receptors to cause a cellular response, such as migration, adhesion and chemotaxis.[12,17] The chemokine family has been classified into four classes: CC, CXC, CX3C, and (X), based on the arrangement of N-terminal cysteine residues.[18] This article mainly discussed the relationship between CXCL8/9/10/11/13 and HNC, as well as the prognosis of gene mutations and related cancers.