Huang et al discovered that CXCL13 highly expressed in cutaneous melanoma than normal tissue and associated with better overall survival.[21] Ignacio et al showed that CXCL13 was related to longer OS in ovarian cancer with wild-type TP53.[22] In contrast, Zheng et al demonstrated that CXCL13 was significantly upregulated in clear cell renal cell carcinoma, and high CXCL13 expression associated with a poor prognosis.[23]. This evidence concerns the gene TP53 and cutaneous melanoma.