Moreover, CXCL8 and its receptors are also involved in the mechanism of CRC cells and circulating CRC cells escaping from immune surveil-lance.[20] Existence of CXCL8 gene reduced the survival pressure of tumor cells to a certain extent, and it built a good growth microenvironment for tumor cells, which also has a great influence on the prognosis and survival of patients with HNC. This evidence concerns the gene CXCL8 and neoplasm.