What is more, a high level of CXCL11 is associated with worse TNM staging in patients with pancreatic cancer (PC), enhancing the proliferation and metastasis of PC cells.[24] Similarly, in our study, CXCL11 was found to express higher in the tissues of patients with HNC than in normal tissues, and was expressively connected with individual cancer staging in patients with HNC. This evidence concerns the gene CXCL11 and pachyonychia congenita.