Indeed, the presence of active infection (COVID-related pneumonia in patient 1 and Aspergillus pneumonia superinfection on patient 3) contraindicated PE and other immunosuppressive approaches; the relatively long temporal distance (14 and 21 days) from the first cycle lead us to consider the second course as acceptably safe; moreover, repeated CSF analysis still showed persistency of raised albumin, likely indicating a still active inflammatory process and thus still active disease. Here, ALB is linked to infection.