In this study, we demonstrated in our Jordanian Arab sample that the risk of HL was almost two-fold in those with the SNP rs5743836 (TLR9-1237T>C), when examined in the dominant, codominant and overdominant models (p-values are 0.025, 0.030 and 0.035 respectively). Here, TLR9 is linked to Hodgkins lymphoma.