CCL2 and Ventriculomegaly: In transgenic mice with myocardial overexpression of MCP-1, leukocyte infiltration into interstitium between cardiomyocytes was increased, which was associated with cardiac hypertrophy, ventricular dilatation, increases in left ventricular mass and systolic and diastolic left ventricular internal diameters, and depressed contractile function [32].