The use of NGS techniques has contributed to the identification of variants associated with AD in this gene [32,114–119], including the Alzheimer’s Disease Sequencing Project (ADSP), which performed a complete sequencing of the 5,740 patients with late-onset Alzheimer’s disease and 5,096 cognitively normal controls, mainly of European descent, which includes 218 cases and 177 controls of Hispanic origin, in which SORL1 has been one of the most prevalent genes [120]. The gene discussed is SORL1; the disease is early-onset autosomal dominant Alzheimer disease.