INS and diabetes mellitus: Infusion of triglycerides into rats induced insulin resistance as assessed by the euglycaemic-hyperinsulinaemic clamp study.37 Consistently, triglycerides in humans were positively associated with insulin resistance, the latter being assessed by homeostatic model assessment for insulin resistance.18 In people without diabetes, increased insulin resistance associated with high triglycerides could be compensated by higher insulin secretion to maintain postprandial glucose homeostasis.