Of note, 2 different algorithms (CIBERSOFT-ABS and QUANTISEQ) indicated that CCR7 considerably associated with M2 macrophage infiltration level in HNSCC (Fig. 1G; CIBERSOFT-ABS Spearman correlation coefficient = 0.581, P = 8.36e−46; QUANTISEQ Spearman correlation coefficient = 0.374, P = 8.89e−18). This evidence concerns the gene CCR7 and head and neck squamous cell carcinoma.