It has been reported to abnormally express in diverse tumor types [24] and has been blamed for enhancing tumor migration, epithelial mesenchymal transition (EMT) and cancer stemness through combination with its two CC motif ligands: CC chemokine ligand 19 (CCL19) and CC chemokine ligand 21 (CCL21) [25, 26]. Here, CCL21 is linked to neoplasm.