By quantifying survival and apoptosis over time, we show significant differences between WT and well‐characterized MORC2 mutants which allow to predict the pathogenicity of two new variants c.1330G>A (p.Gly444Arg) and c.1338C>A (p.His446Gln) of the MORC2 gene respectively associated with an autosomal dominant form of CMT and with adult late onset proximal motor neuropathy. The gene discussed is MORC2; the disease is Onset.