An earlier study reported that leukocytes synthesize AGT.58 Although macrophages are the major cell type accumulated in mouse atherosclerotic lesions, bone-marrow transplantation of AGT deficient leukocytes did not reduce hypercholesterolemia-induced atherosclerosis in LDL (low-density lipoprotein) receptor−/− mice,59 suggesting that leukocyte-derived AGT does not affect atherosclerosis. This evidence concerns the gene AGT and familial hypercholesterolemia.