Pharmacological inhibition of renin, ACE, or the AT1 receptor does not have these beneficial effects in mouse metabolism.59 Also, there is no solid evidence that ACE inhibitors and ARBs improve obesity or liver steatosis in humans.70–72 AGT is cleaved by renin into 2 products: one is Ang I (10 amino acids) that is further cleaved into Ang II (8 amino acids) by ACE, and the other product is des(Ang I)-AGT (443 amino acids in mice and 442 amino acids in humans). The gene discussed is AGT; the disease is obesity due to melanocortin 4 receptor deficiency.