In conclusion, our data suggested the potential role of miRNAs favoring the preponderance of pathways compromising beta cell function throughout diabetes progression like increased apoptosis, inhibition of EMT, impaired TREG function, inflammatory pathways like STAT3 and PTEN, and senescence probably being indirect signs of islet autoimmunity and metabolic derangements due to gluco-lipid toxicity. This evidence concerns the gene PTEN and diabetes mellitus.