The worsening of beta cell function, dysregulation of glucose levels, and insulin resistance probably accounted for the progressive upregulated trend of the expression of these miRNAs toward the T1D 2-5y group, particularly for miR-518b and miR-323a-3p, interfering negatively with beta cell expansion [14] and insulin secretion [36]. Here, INS is linked to type 1 diabetes mellitus.