In summary, three of the FRLs (LOC100507144, LINC02269, and EBLN3P) in the prognostic model were reported to be upregulated in ESCC, in contrast to the remaining seven lncRNAs (SNHG29, RB1-DT, MEG3, LINC01970, FAM13A-AS1, CAHM, and APOA1-AS). This evidence concerns the gene RB1 and esophageal squamous cell carcinoma.