Compared with the total open surgery group, the total laparoscopic surgery group demonstrated the following features: a lower proportion of patients with liver metastasis bilobar distribution (23.33% vs. 56.29%, p < 0.001), primary right-sided CRC (16.67% vs. 67.55%, p < 0.001), and braf gene mutation (0.00% vs. 5.88%, p = 0.030), and a higher proportion of patients who underwent preoperative chemotherapy (60.00% vs. 39.74%, p = 0.008) and patients with less liver metastasis [1.00 (1.00–2.00) vs. 2.00 (1.00–5.00), p < 0.001]. Here, BRAF is linked to colorectal carcinoma.