IGF1R and cancer: Nutraceuticals have a great potential to modulate various molecular targets, such asgrowth factors [e.g., epidermal growth factor receptor (EGFR), insulin-like growth factor-1 receptor (IGF-1R), HER2, and VEGFR], transcription factors [e.g., STAT3, NF-κB, NRF-2, activator protein (AP-1), HIF-1α and peroxisome proliferator-activated receptor (PPARγ)], protein kinases [e.g., Bcr-abl, phosphoinositide 3-kinase (PI3K), Raf/Ras and AMPK], inflammatory mediators [e.g., TNF-α, 5-LOX, COX-2, CRP, IL-6, IL-8, and iNOS], and other targets that are involved in cancer progression (116).