AKT1 and cancer: Many nutraceutical products such as soy isoflavones, curcumin, resveratrol, indole-3-carbinol, lycopene, green tea polyphenols, epigallocatechin-3-gallate, and 3,3’-diindolylmethane (DIM) cause downregulation of signal transductions such as Akt, PI3K, NFkB, mTOR and other pathways that are required for cancer progression (26).