Among Hispanics, PFS was higher in those with better ECOG [ECOG 0: 21.4 months (95%CI 17.8-25.1) vs. ECOG 1: 10.2 months (95%CI 4.6-15.7); P=0.19] (Supplementary Figure S3), in patients with SCC [25.5 months (95%CI 20.2-30.8) vs. Adenocarcinomas 15.5 (CI95% 12.8-18.3); P=0.06] (Supplementary Figure S4) and in those with higher PD-L1 expression [PD-L1 ≥50% PFS NR, PD-L1 1-49% 14.5 months (95%CI 8.8-NR) and PD-L1 <1% 12.3 months (95%CI 6.8-13.6); P=0.001]. Here, CD274 is linked to adenocarcinoma.