HSP90B1 and neoplasm: As a major component of the HSPPC-96 vaccine, gp96 is a molecular chaperone in the endoplasmic reticulum (ER) that has been reportedly linked to maintaining the ER stability (68), mediating unfolded protein responses (69, 70), promoting tumor invasiveness (71) as well as facilitating activation of adaptive and innate immune responses (72).