We further detected their mRNA expression with PCR and found significant difference in ACVR2A, CDC27, CDH1, CDKN2A, CTCF, IL32, ALRP4B, NUDT11, POLDIP2, PTEN, PTH2 and RHOA between tumor and normal tissue (Supplementary Figure 3). Here, CTCF is linked to neoplasm.