Unlike melanoma cells harbouring BRAFV600E that upregulated IGF1-R in response to ERK1/2i (Benito-Jardón et al., 2019), melanoma cells harbouring NRASQ61L/K increased PDGRβ, and the increase ERK5 phosphorylation was sensitive to the PDGFRi’s, crenolanib, and CP673451 (Figure 3). This evidence concerns the gene MAPK3 and melanoma.