Gene targeting strategies to knock-out ERK5 in tumour-associated macrophages impedes the growth of melanoma (and lung carcinoma) in mouse models (Giurisato et al., 2018; Giurisato et al., 2020), and whole mouse conditional ERK5 knockout reduces tumour neo-vascularization of a melanoma xenograft (Hayashi et al., 2005). Here, MAPK7 is linked to melanoma.