These authors also established that insulin-like growth factor receptor 1 (IGF-1R) was upregulated (by stabilization) and ERK1/2i-resistant melanoma cells were dependent on IGF1-R activity (using the IGF1-R inhibitor, linsitinib) for cell proliferation in vitro, in spheroids and in xenograft models. The gene discussed is MAPK3; the disease is melanoma.