Nutritional immunity imposed by NRAMP1 is a significant defense determinant against Salmonella as vividly illustrated by the high resistance of Sv129S6 or C3H/HeN mice carrying an intact nramp1 locus and the propensity of BALB/c or C57BL/6 mice bearing the mutant allele nramp1G169D to develop severe Salmonella infections (Brown et al., 2013; Wendy P.; Loomis et al., 2014). The gene discussed is SLC11A1; the disease is Salmonella Infections.