In mice, continuous activation of the Ha-ras gene could cause non-invasive bladder cancer, while introduction of UP II promoter to SV40T gene functionally inhibited expression of p53 and pRb genes and caused development of invasive bladder cancer in experimental mice (Zhang et al., 2001; Cordon-Cardo, 2008). This evidence concerns the gene TP53 and urinary bladder carcinoma.