IKAROS IK6 is unable to bind DNA to regulate the expression of genes required for B-cell differentiation, implying that JAK2r and IKZF1 deletions both drive deregulation of B-cell maturation and promote development of B-ALL (Mullighan et al., 2009b; Harvey et al., 2010; Pui et al., 2017). This evidence concerns the gene IKZF1 and precursor B-cell acute lymphoblastic leukemia.