CD4 and neoplasm: Notably in our model, the factor that CD4 T cells induced the highest increase of production by TAMs, both at the transcriptional and protein level, was CXCL9 which has been found to be a good predictor of the antitumor response obtained by checkpoint inhibitors (41, 42), suggesting that this therapeutic modality might be using similar mechanism of TAM education, by inhibiting negative signals given by antigen-presenting TAMs to CD4 T cells at the tumor site and increasing IFNγ production.