Third, the hindered antitumor effect observed when none of the TAMs could receive IFNγ signal (AbγRKO, red circle) is similar to the minimal effect observed when only the TAMs lacking CD4 cognate interaction could receive IFNγ signal (AbγRKO+Ak, red squares; Fig. 7B), suggesting that just IFNγ signaling on TAMs is not sufficient to induce tumor rejection. This evidence concerns the gene CD4 and neoplasm.