Although we initially showed the importance of CD4 T cells in tumor rejection in immunocompetent wild-type mice, we next moved to “immunocompromised” RAGKO mice as tumor bearing hosts to allow us to definitively demonstrate the significance of TAM and CD4s interactions without the distractions afforded by helped CD8 T cells, natural killer T cells or regulatory T cells (Treg). Here, CD8A is linked to neoplasm.