MAPT and Cognitive impairment: For example, increased CSF p- and t-tau levels were correlated with EEG slowing and decreasing synchronization in patients with cognitive impairment (Smailovic et al., 2018; Tanabe et al., 2020); the combined p-tau/Aβ42 ratio exhibited a stronger correlation with the slow-frequency band in elderly individuals (Stomrud et al., 2010).