Aside from the well-characterized extracellular amyloid plaques and neurofibrillary tangles composed of β-amyloid (Aβ) and phosphorylated tau proteins, an early pathology in AD is the loss of functional synapse and disruption in synaptic plasticity that occur before overt neurodegeneration (Cleary et al., 2005; Hsieh et al., 2006; Lacor et al., 2007; Shankar et al., 2007; Chen et al., 2010; Kim et al., 2014; Chung et al., 2016). This evidence concerns the gene MAPT and Alzheimer disease.