Studies have shown that the concentration of HMGB-1 in sputum and plasma samples of the patients with chronic obstructive pulmonary disease was significantly increased compared with that in a normal control group [8, 9], indicating that HMGB1 is involved in the remodeling of the airway and pulmonary vascular structure, which ultimately lead to HPH. Here, HMGB1 is linked to chronic obstructive pulmonary disease.