OGG1 and hearing loss disorder: Shen et al. (2014) designed research to investigate the relationship between the gene polymorphism (hOGG1 Ser326Cys) of rs1052133 and susceptibility to high frequency hearing loss. The hOGG1 Cys/Cys genotype was found to be a possible risk factor for high-frequency hearing loss, and stratified analysis revealed it was also associated with risk factors such as years of work in noisy jobs, noise exposure level and smoking. Thus, they concluded that the hOGG1 Cys/Cys genotype may be a risk factor for high frequency hearing loss in the Chinese Han population.