NOX3 and noise induced hearing loss: Xin et al. (2021) conducted a case-control study in five factories in China, and illustrated the association between rs12195525 and NIHL susceptibility. For further exploration, Lavinsky et al. (2015) verified that Nox3 is involved in NIHL susceptibility in Nox3het/Nox3het and Nox3het/ + mutant mice, which was frequency specific at 8 kHz.