Van Eyken et al. (2007) performed a study to investigate the association between the GJB2 35delG mutation and the development of NIHL. Frustratingly, the results suggested that 35delG carriers had no increased susceptibility to the development of NIHL. However, in an animal study, Zhou et al. (2016) established a Connexin26 knockdown mouse model to investigate the relationship between Connexin26 gene and NIHL. Their results indicated that decreased Connexin26 expression may contribute to the increased susceptibility to NIHL and promote the cell degeneration in the Corti’s organ. This evidence concerns the gene GJB2 and noise induced hearing loss.