PON2 and noise induced hearing loss: Li X. et al. (2016) studied the polymorphisms of rs12026, rs7785846, and rs12704796 in PON2 in 221 patients with NIHL and 233 subjects with normal hearing by logistic regression analysis. It was found that rs12026 CG and CG + GG genotypes and rs7785846 CT and CT + TT genotypes were highly susceptible to NIHL. Wu et al. (2020) confirmed these results that PON2 gene affects the NIHL susceptibility of cochlea.