Among the genes, 1-hop and 2-hop neighbors in the underlying network, were chromatin licensing and DNA replication factor 1 (CDT1), minichromosome maintenance complex component 5 (MCM5), and cAMP-responsive element-binding protein 1 (CREB1), which have been linked to ischemic heart disease before. This evidence concerns the gene MCM5 and coronary artery disorder.