Therefore, combined with the multiple related genes we screened (including STN1, STMN3, PRRC2A), we speculate that the telomere shortening inhibitory pathway in tumors has been determined at birth.when telomeres are too long, the telomere reserve will not be depleted in time, which will provide additional divisions for cancer cells, especially for familial-prone tumors (melanoma glioma, non-Hodgkin lymphoma, etc.)(Nieters et al., 2012; Feng et al., 2018; Ali et al., 2021). Here, PRRC2A is linked to cancer.