PIK3CD encodes the phosphatidylinositol 3-kinase (PI3K) catalytic subunit P110 δ related to cancer, and PIK3C deactivates the AKT/GSK-3 β/β-catenin signaling pathway, promoting the occurrence and development of colorectal cancer (Chen et al., 2019). The gene discussed is PIK3CD; the disease is colorectal cancer.