Many of the genes for proteins acting up- and down-stream of RIP2 such as Nod1, Uev1a, Ubc13, Traf1, Traf6, Tak1, and Bid were significantly upregulated in WT mouse OM, peaking from 3 h to 1 day after inoculation. The gene discussed is TRAF1; the disease is ocular melanoma.