Rashu et al. (2020) describe two adult LIPA compound heterozygous siblings for the c.894G > A and c.482del variants and Gürbüz et al. (2020) report a 14-year-old and 3-year-old siblings with homozygous c.894G > A variant with persisting gastrointestinal symptoms (hepatosplenomegaly, malabsorption, and diarrhea, combined with elevated transaminases and dyslipidemia). A Columbian boy was confirmed with LAL-D with the c.893G > A variant in the LIPA gene at age 14 after isolated hepatomegaly and dyslipidemia at age 6 were detected (Botero et al., 2018). This evidence concerns the gene LIPA and metabolic syndrome.