LIPA and Wolman disease: Depending on the genetic variant in the LIPA gene and consequently residual lysosomal acid lipase (LAL) activity, LAL-D can result in the very severe, infantile-onset, and lethal form known as Wolman disease, or in the milder, late-onset phenotype, known also as cholesteryl ester storage disease (CESD) (Reiner et al., 2014; Pullinger et al., 2015; Sjouke et al., 2016; Maciejko, 2017).