In the meta-cohort, univariate Cox regression analysis uncovered that 15 ferroptosis regulators, namely, CRYAB, HSPB1, GLS2, GOT1, FANCD2, CHAC1, PTGS2, ALOX15, ACO1, NFS1, CD44, GPX4, TFRC, TP53, and FADS2 exhibited significant correlations to GC prognosis (Figure 2G; Supplementary Figure S1). The gene discussed is HSPB1; the disease is gastric cancer.