Luo et al. found that crude polysaccharides from D. huoshanense could inhibit the oxidation pathway by the down-regulation of inducible nitric oxide synthase (iNOS) gene expression and advanced glycation end product (AGEs) formations to suppress diabetic cataract, which is an important cause of blindness worldwide (Luo et al., 2008). Here, NOS2 is linked to diabetes mellitus.