In conclusion, this study applied the method of network pharmacology to study the complex molecular network relationship between RDN and sepsis, and found that RDN may regulate core genes such as AKT1, IL-6, TNF, and PTGS2 through active ingredients such as Stigmasterol, Kaempferol, Quercetin, beta-sitosterol, and Corymbosin, thus improving the endothelial cell damage caused by LPS. The gene discussed is IL6; the disease is Sepsis.