EGFR and cancer: As shown in Figures 3B, 87 signal pathways were enriched, largely in major cancer pathways, lipid, and atherosclerosis, calcium signaling pathway, stimulating neural tissue interaction, Rap1 signaling pathway, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance, AGE-RAGE signaling pathway, cancer center carbon metabolism, and PI3K-AKT signaling pathway, etc.