Compound 35 was shown to be an inhibitor of NAMPT (IC50 = 242.7 nM) by virtual screening based on structure and ligand, and showed a protective effect when tested in axonal cell models, suggesting that inhibition of NAMPT may be an effective treatment for neurodegenerative diseases (Clark et al., 2016) (Figure 8). The gene discussed is NAMPT; the disease is neurodegenerative disease.