MAPK8 and neoplasm: Consistently, RasV12/lgl−/− tumour in larva obviously increased the mRNA level of c-FOS that encodes one component of AP-1 (JNK downstream transcription complex) (Uhlirova and Bohmann, 2006), and the increased c-FOS transcription was notably impeded by XFZYD at the concentration of 3.13 g/L through a qRT-PCR assay (Figure 8A).