In another study, resveratrol derivative-rich melinjo seed extract was found to have a potent impact on inflammation-induced bone loss in a murine model of established periodontitis as indicated by a reduction in osteoclast differentiation (Ikeda et al., 2018) The production of IL-1β in gingival tissue was reduced but no significant changes in IL-6, TNF-α, and IL-17 levels were observed. This evidence concerns the gene TNF and periodontitis.