Moreover, compared with the very low CBFB expression in HMF3A cells and the nontumorigenic breast epithelial cell line MCF10A, CBFB expression was mildly elevated in the MCF7 and T74D breast cancer cell lines with low metastatic potential and markedly upregulated in the highly metastatic MDA-MB-436 and MDA-MB-157 cells (CBFB: MDA-MB-436, MDA-MB-157>>MCF7, T47D>MCF10A, HMF3A) (Figure 1(c)). The gene discussed is CBFB; the disease is breast cancer.