We also demonstrated that the CBFB-rich serum exosomes from patients with bone metastasis facilitated the acquisition of metastatic phenotypes by breast cancer cell lines that were hitherto less metastatic or nonmetastatic (Figure 2); these enhanced migration and invasion capabilities were associated with an increased expression of EMT markers, such as Snail, vimentin, and CD44, as well as bone metastasis markers OPN and Runx2. This evidence concerns the gene SPP1 and breast carcinoma.