Such developments include the use of antibiotics to treat pulmonary infections, dietary modifications to increase fat and caloric intake, use of pancreatic enzymes, anti-pseudomonal therapies, early identification and intervention through newborn screening, use of mucolytics, and treatment with CFTR modulators, all of which have played a critical role in improving the life expectancy and quality of life for individuals with CF. The gene discussed is CFTR; the disease is cystic fibrosis.