In mice fed a diet deficient in methionine and choline (simulating conditions experienced during non-alcoholic steatohepatitis), administration of the PPARδ agonist GW501516 and the pan-agonist bezafibrate markedly reduced hepatic TAG and lipid droplet size in hepatocytes (47); on the other hand, the same PPARδ agonist failed to reduce liver TAG in mice consuming a “Western type” high-fat diet, though circulating plasma TAG were significantly lower (48). The gene discussed is PPARD; the disease is metabolic dysfunction-associated steatohepatitis.