Acetylation of histone 3 lysine 9 at the promoter region of DBP, and its consequent upregulation, plays a role in regulation of glucose homeostasis and is related to PPARγ in mice (98) and humans with type 2 diabetes (99), while TRIB3 affects response to insulin by inhibiting Akt phosphorylation (100), and its activity is directly related to that of PPARγ (101). Here, INS is linked to type 2 diabetes mellitus.