Moreover, SP genetic polymorphisms have been shown to associate with RSV (27–30), as well as other pulmonary diseases, such as neonatal respiratory distress syndrome (RDS) (31–35), cystic fibrosis (CF) (36), chronic obstructive pulmonary disease (COPD) (37, 38), acute respiratory distress syndrome (ARDS) (23), hypersensitivity pneumonitis (39, 40), pediatric acute respiratory failure (ARF) (41), and persistent respiratory morbidity in pediatric ARF survivors (42). Here, TFF2 is linked to chronic obstructive pulmonary disease.