Cox proportional hazards (COX-PH) models and survival curve analysis revealed that the high ssGSEA score of the tumor intermediate state and the CD8+ T exhausted state both significantly predicted favorable overall survival (OS) in the TCGA-SKCM cohort (intermediate: HR = 0.118, coxph p = 1.64e-05, log-rank p = 0.00038; exhausted: HR = 0.104, coxph p = 1.29e-07, log-rank p < 0.0001) (Figures 7A–C), as well as progression-free interval (PFI) (intermediate: HR = 0.391, p = 0.0345; exhausted: HR = 0.403, p = 0.00883) (Figure 7A). This evidence concerns the gene CD8A and neoplasm.