Positive associations were significant between interferon-gamma response and ssGSEA scores of the tumor intermediate state and the CD8+ T exhausted state in the TCGA-SKCM cohort (intermediate: R = 0.46, p < 2.2e-16; exhausted: R = 0.62, p < 2.2e-16) (Figure 7E). This evidence concerns the gene IFNG and neoplasm.