Thus, it is rationale to predict that in moderate cases, SARS-CoV-2 induced ISGs activation, the latter one leaded to the constitutively expression of MX1/2 and IFIT1/2, which then extended and enhanced the anti-viral activity of innate response, thereby alleviate the symptoms of COVID-19 and overcome SARS-CoV-2 viral evasion in CMs. This evidence concerns the gene IFIT1 and COVID-19.