Otherwise, circulating B-cells secrete increased amounts of IL-8, IL-1β, BAFF, and CXCL13, which are proinflammatory, profibrotic cytokines or chemo-attractant molecules, both in scleroderma mouse models and SSc patients (20, 22, 37, 84). Here, TNFSF13B is linked to systemic sclerosis.