Large-cohort genomic studies have identified associations between genes involved in B-cell signaling and the SSc phenotype, including B-cell scaffold protein with ankyrin repeats 1 (BANK1), B lymphoid kinase protein (BLK), c-src tyrosine kinase (CSK) or intracellular protein tyrosine phosphatase (PTNP22) genes (47). The gene discussed is CSK; the disease is systemic sclerosis.