IL10 and systemic sclerosis: Thus, B-cell subsets in SSc patients are unbalanced, with an expansion of naive and transitional B-cells with a decrease in memory B-cells, switched memory B-cells, and IL-10+-producing regulatory B-cells (Bregs), particularly in steroid-untreated patients (16, 18–20, 22, 24–27), with a higher circulating plasma cell molecular signature (28).