Klotho-deficient mice exhibit stunted growth, renal disease, hyperphosphatemia, hypercalcemia, vascular calcification, cardiac hypertrophy, hypertension, organ fibrosis, multi-organ atrophy, osteopenia, pulmonary disease, cognitive impairment and short lifespan (Bian et al., 2015; Erben and Andrukhova, 2017; Kinoshita and Kawai, 2016; Kuro-o et al., 1997, 2010, 2019, 2021). This evidence concerns the gene KL and Cognitive impairment.