A disorder of this sort was recently found to be associated with loss‐of‐function variants of CLDN10, resulting in the autosomal recessive HELIX syndrome characterized by hypohidrosis, electrolyte imbalance, lacrimal gland dysfunction, ichthyosis, and xerostomia (OMIM 617671; prevalence: <1/1,000,000).32, 33, 34, 35, 36, 37. Here, CLDN10 is linked to hypohidrosis.